Comprehensive analyses of causative genes for intellectual disability and autism-spectrum disorders

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390271
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: Nagata Koh-ichi 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 部長 (50252143)
• Co-Investigator(Kenkyū-buntansha): 山形 崇倫 自治医科大学, 医学部, 教授 (00239857) ; 原 明 岐阜大学, 医学(系)研究科(研究院), 教授 (10242728)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 自閉性障害 / 知的障害 / 大脳皮質構築 / 神経細胞

Outline of Final Research Achievements

While many different biological causes have been implicated in the etiologies of neurodevelopmental disorders such as autism-spectrum disorder (ASD) and intellectual disability (ID), genetic factors are considered to be the most important. Thus, it is essential to clarify the pathophysiological significance of respective disease-related genes in brain development. To address this issue, we have established a battery of in utero electroporation-based ex vivo and in vitro observations including cortical neuron migration, axon elongation, dendrite development, spine morphogenesis and live-imaging as well as cell biological and biochemical analyses.

Free Research Field

小児神経科学