Translational and clinical studies for sophistication of heavy ion therapy for cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390288
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: Nakano Takashi 群馬大学, 医学(系)研究科(研究院), 教授 (20211427)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Yoshiyuki 群馬大学, 大学院医学系研究科, 教授 (60334116) ; OHNO Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061) ; NODA Shin-ei 群馬大学, 医学部, 講師 (60396645) ; KATOH Hiroyuki 群馬大学, 重粒子線医学推進機構, 助教 (30334121) ; SAITO Junichi 群馬大学, 大学院医学系研究科, 准教授 (70572816) ; TAMAKI Tomoaki 福島医科大学, 大学院医学系研究科, 准教授 (20400749) ; SHIRAI Katsuyuki 群馬大学, 大学院医学系研究科, 講師 (10400748) ; YOSHIDA Yukari 群馬大学, 重粒子線医学推進機構, 助教 (90431717)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 重粒子線 / 放射線治療 / 放射線生物学 / 粒子線治療 / 放射線腫瘍学

Outline of Final Research Achievements

This study promoted translational research for innovative heavy ion therapy to elucidate characteristic biological effects of carbon ions and preferable cancers for carbon therapy and also to develop optimal methods of the treatment. Results of the research were strong biological effect of heavy ions being related to NHEJ gene repair mechanism, carbon beam therapy for locally advanced lung cancer enhance local control with combination with anti-cancer drugs, carbons increase the cell migration ability of A549 lung cancer cells through the Rho signaling pathway, antigen-specific anti-tumor immunity being activated in cancer patients with radiation therapy, intravenous administration of dendritic cells augment anti-tumor immune with combination of carbon therapy to suppress the lung metastasis, greater enhanced effect of carbon therapy being expected for EGFR mutation-negative lung cancers, the combination of radiation and mTOR inhibitors sensitizing radiation effect under hypoxia.

Free Research Field

放射線腫瘍学、重粒子線治療、放射線生物学