2014 Fiscal Year Final Research Report
Identification of pancreatic cancer stem cell lineage during pancreatic tumorigenesis
| Project/Area Number |
24390305
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Hideki 横浜市立大学, 医学研究科, 教授 (70292555)
TAKEBE Takanori 横浜市立大学, 医学部, 准教授 (20612625)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 癌 / 細胞・組織 |
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| Outline of Final Research Achievements |
Pancreatic cancer tissues were harvested from different carcinogenesis stages of pancreatic model mice. The cells were separated by cell sorter using a specific antibody that recognizes a number of surface antigens known as a cancer stem cell marker. The separated cells were examined either have a capability as cancer stem cells. Cancer stem cells collected from mice with progressed cancer were found to have metastatic potential in addition to the tumor forming potency. Furthermore, pancreatic cancer stem cells with tumor -forming ability that was separated from the carcinogenic early pancreatic cancer tumor tissue does not have a metastatic potential, but the metastatic potential succeed planting cells of pancreatic cancer xenografts, which is formed from this carcinogenesis early cancer stem cells in a xenograft It revealed to exacerbate into cells having .
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| Free Research Field |
幹細胞生物学
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