Development of neutron capture therapy using intra-arterial injection of cancer specific emulsion by membrane emulsification technique

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390311
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Yanagie Hironobu 東京大学, 工学(系)研究科(研究院), 研究員 (30212278)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Hiroyuki 東京大学, 大学院工学系研究科(工学部), 教授 (70216753)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 中性子捕捉療法 / ボロン化合物 / ガドリニウム化合物 / ＷＯＷエマルション / エストロゲン骨格 / 二段階肝動注ターゲティング法 / 腫瘍マーカー / 肝臓癌と乳癌

Outline of Final Research Achievements

The purpose of this project is to develop a novel tumor selective emulsion for applicating boron neutron capture therapy(BNCT). We had been able to achieve 170/58.3 ppm in 24hrs/72hrs, respectively, which was exceeded more than 30ppm, as the effective boron concentration for BNCT in VX-2 rabbit hepatic tumour model. Apoptosis was recognized in the tumour by BNCT after intra-arterial hepatic injection of 10BSH entrapped WOW emulsion. Cancer cell cytotoxicity of mouse breast cancer cell line was recognized by BNCT using natural boron binding estrogen compound, and this cytotoxicity was lower than the effect using 10Borono-phenylalanine(BPA). These results showed that it was more effective to develop the cancer selective accumulating compounds as second targeting than to develop the cancer selective modification of surface of WOW emulsion as first targeting.

Free Research Field

消化器外科