Bridging research for development of non-surgical treatments against cerebral aneurysms

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390342
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: NOZAKI Kazuhiko 滋賀医科大学, 医学部, 教授 (90252452)
• Co-Investigator(Kenkyū-buntansha): JITO Junya 滋賀医科大学, 医学部, 助教 (50534161) ; INUBUSHI Toshiro 滋賀医科大学, 分子神経科学研究センター, 教務補佐員 (20213142) ; SHINO Akihiko 滋賀医科大学, 分子神経科学研究センター, 准教授 (50215935) ; TORII Ryuzo 滋賀医科大学, 動物生命科学研究センター, 教授 (50106647) ; NAKAMURA Shinichiro 滋賀医科大学, 動物生命科学研究センター, 准教授 (50307980)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: cerebral aneurysm / animal model / molecular mechanism / macrophage / MR imaging

Outline of Final Research Achievements

We analyzed the possible role of TNF-α, Interferon cascades on the development, growth and rupture of cerebral aneurysm in a rat model and performed histological and MR imaging studies in a monkey model. We also evaluated the effect of statins and other anti-inflammatory agents on the development, growth and rupture of experimentally-induced cerebral aneurysms using histological analysis and MR imagings in rat and monkey models.

Free Research Field

脳血管障害