2015 Fiscal Year Final Research Report
Functional analysis of ADAMs in the musculoskeletal and hematopoietic system
| Project/Area Number |
24390358
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YODA Masaki 慶應義塾大学, 医学部, 特任助教 (30464994)
TOHMONDA Takahide 慶應義塾大学, 医学部, 特任助教 (40415237)
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| Co-Investigator(Renkei-kenkyūsha) |
TOYAMA Yoshiaki 慶應義塾大学, 医学部, 教授 (40129549)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 骨軟骨代謝 / 筋代謝 / ADAM遺伝子 / 小胞体ストレス |
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| Outline of Final Research Achievements |
In the present study we analyzed the functions of ADAM10 and ADAM17 in the musculoskeletal system. Specifically, we found that 1) ADAM17 regulates longitudinal bone growth via indirectly regulating osteoclastic bone resorption, that 2) ADAM17 specifically cleaves the decoy receptor IL-1R2 and thereby positively regulates IL-1 signaling, and that the activity of ADAM17 is not dependent on transcriptional or translational regulation. As for ADAM10, we found that ADAM10 plays an indispensable role in maintaining satellite cells in skeletal muscle. In addition to these study, we also investigated the potential role of ER stress in osteoclasts and identified a stress sensor IRE1α as a novel regulator of osteoclastogenesis.
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| Free Research Field |
医歯薬学
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