2014 Fiscal Year Final Research Report
Novel autoantibody markers for ACPA negative RA patients
| Project/Area Number |
24390360
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IKARI Katsunori 東京女子医科大学, 医学部, 准教授 (80343557)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 自己抗体 / 関節リウマチ |
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| Outline of Final Research Achievements |
We tried to define novel autoantibody markers for ACPA negative RA patients using the ProtoArray human protein microarray and ProtoPlex. Candidates were as follows: pogo transposable element with ZNF domain (POGZ), transcript variant 3, Aryl hydrocarbon receptor nuclear translocator, TIMELESS interacting protein (TIPIN), serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), interferon regulatory factor 3 (IRF3), protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 1, RUN and FYVE domain containing 3 (RUFY3), TBC1 domain family member 22B, hypothetical protein MGC13057 (MGC13057), transcript variant 4, chromosome 16 open reading frame 53 (C16orf53), solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1), MRG-binding protein, tec protein tyrosine kinase (TEC), KIAA0513 (KIAA0513).
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| Free Research Field |
整形外科学
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