Effects and the mechanism of action by remifentanil in the brain protection strategy

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390364
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokyo
• Principal Investigator: Uchida Kanji 東京大学, 医学部附属病院, 准教授 (60302709)
• Co-Investigator(Kenkyū-buntansha): YAMADA Yoshitsugu 東京大学, 医学部附属病院, 教授 (30166748) ; IMAI Hideaki 東京大学, 医学部附属病院, 講師 (70359587)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: レミフェンタニル / 脳保護 / 術後予後 / 開頭手術

Outline of Final Research Achievements

Propensity-matched analysis of administrative claims database indicated that the use of remifentanil associated with improved outcome of the patients undergoing surgical clipping of intracranial aneurysm. Use of remifentanil associated with reduced postoperative death with odds ratio of 0.52 ( 95% CI 0.37-0.74 p<0.001). Animal craniotomy model using rats revealed that the use of intraoperative remifentanil associated with suppressed recruitment of white blood cells to the peripheral blood. We have also standardized GM-CSF autoantibody ELISA and quantify reactivity of circulating neutrophils to exogenous GM-CSF to evaluate GM-CSF bioactivity that is important to the innate immunity agains the invading pathogen, as well as repair of the wound.

Free Research Field

麻酔学、集中治療医学