2014 Fiscal Year Final Research Report
A novel therapeutic strategy for prostate cancer treatment with anti-cancer immunological proteins.
| Project/Area Number |
24390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKU Haruki 岡山大学, 岡山大学病院, 講師 (60346426)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | サイトカイン / 癌 / STAT / 癌免疫 |
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| Outline of Final Research Achievements |
Recently, we found that secreted REIC/Dkk-3 protein induces differentiation from monocytes to dendritic cell-like cells. Until now, the anti-cancer effects of REIC/Dkk-3 protein have been also reported. In this study, we identified and purified a 17 kDa cysteine-rich stable product of the REIC/Dkk-3 protein (17kDa REIC/Dkk-3) which shows the protein character of limited degradation. We herein demonstrated that the C17-REIC indicates anti-cancer effects in response to intraperitoneal administration and its effects on the activation of immunocompetent cells in blood.
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| Free Research Field |
泌尿器科学
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