Elucidation of the roles of placental microRNAs in the pathogenesis of preeclampsia and identification of novel prognostic factors for preeclampsia

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390383
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nippon Medical School
• Principal Investigator: TAKIZAWA Toshihiro 日本医科大学, 医学(系)研究科(研究院), 教授 (90271220)
• Co-Investigator(Kenkyū-buntansha): TAKESHITA Toshiyuki 日本医科大学, 大学院医学研究科, 教授 (60188175) ; OHKUCHI Akihide 自治医科大学, 医学部, 准教授 (10306136) ; KIKUCHI Kunio 日本医科大学, 医学部, 講師 (70374676)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 産科学 / 妊娠 / 胎盤 / マイクロRNA / 妊娠高血圧腎症

Outline of Final Research Achievements

We showed that exosome-mediated transfer of placenta-associated microRNAs and subsequent modulation of their target genes occurs into maternal cells. We also found that miR-210 and miR-518c that were aberrantly expressed in preeclamptic placenta may serve as risk factors in the pathogenesis of preeclampsia. Plasma level of HSD17B1 in the second trimester is an independent risk factor for predicting preeclampsia. This study provides novel insight into our understanding of molecular pathogenies of preeclampsia.

Free Research Field

産科学、胎盤学、分子腫瘍学、分子病理解剖学