Central and peripheral control of ingestion function

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390431
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Niigata University
• Principal Investigator: INOUE Makoto 新潟大学, 医歯学系, 教授 (00303131)
• Co-Investigator(Kenkyū-buntansha): HORI Kazuhiro 新潟大学, 医歯学系, 准教授 (70379080) ; TANIGUCHI Hiroshige 新潟大学, 医歯学総合病院, 講師 (80529636) ; TSUJIMURA Takanori 新潟大学, 医歯学系, 助教 (00548935) ; NAKAMURA Yuki 新潟大学, 医歯学系, 助教 (70452779) ; MAGARA Jin 新潟大学, 医歯学総合病院, 助教 (90452060)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 咀嚼 / 嚥下 / 歯科 / リハビリテーション

Outline of Final Research Achievements

From human and animal studies, we successfully clarified the followings. 1) Initiation of reflex swallowing is not affected by oral inputs but by chewing behavior or activation of chewing central pattern generator. 2) Motor pattern of swallowing is not affected by conditioning stimulation such as peripheral stimulation. 3) Because there is a positive correlation between effect of central inputs and peripheral inputs on the initiation of swallow, inter-individual variation of initiation of swallow is dependent on the excitability of neural activity in the lower brain stem. 4) repetitive pharyngeal stimulation shortly inhibits the excitability involved in the swallowing center but facilitates that involved in voluntary swallow in the long term.

Free Research Field

嚥下障害学