2014 Fiscal Year Final Research Report
Study on the prevention therapy for the invasion and metastasis of oral cancer by the suppression of E-cadherin processing
| Project/Area Number |
24390455
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬保健学研究院, 教授 (00169153)
新谷 智章 広島大学, 病院, 助教 (90403518)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 口腔癌 / カドヘリン / プロセシング / アンチプラスミン / 浸潤・転移 / 細胞間接着 / 増殖能 |
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| Outline of Final Research Achievements |
Transfection of oral squamous cell carcinoma (SCC) cells with a mammalian expression vector containing α2-antiplasmin cDNA reduced cyclin D1 expression and led to the suppression of the proliferation and tumorigenicity in SCC cells. Induction of α2-antiplasmin led to the decrease in β-catenin expression in the cytosol of SCC cells. Therefore, the inhibition of E-cadherin processing induced by α2-antiplasmin might down-regulate the proliferation of SCC cells via Wnt/β-catenin signaling.
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| Free Research Field |
口腔外科学
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