• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Establishment of the medical support to inpatients by oral health management applied with Kampo medicine

Research Project

  • PDF
Project/Area Number 24390471
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Social dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

HINODE Daisuke  徳島大学, 大学院医歯薬学研究部, 教授 (70189801)

Co-Investigator(Kenkyū-buntansha) IGA Hiroki  徳島大学, 大学院医歯薬学研究部, 教授 (40175188)
YOSHIOKA Masami  徳島大学, 大学院医歯薬学研究部, 准教授 (90243708)
KAWAZOE Kazuyoshi  徳島大学, 大学院医歯薬学研究部, 教授 (00248296)
YOSHIDA Kaya  徳島大学, 大学院医歯薬学研究部, 講師 (60363157)
DOI Tokiko  徳島大学, 大学院医歯薬学研究部, 助教 (70747683)
Project Period (FY) 2012-04-01 – 2016-03-31
Keywords漢方薬 / 歯周病原細菌 / 専門的口腔ケア / 抗がん剤 / 口腔粘膜炎 / 食道がん / 口腔保健管理 / 大黄甘草湯
Outline of Final Research Achievements

The results of basic research indicated that the increase of reactive oxygen species production was consider to be associated with the cell death induced by 5-FU and TJ-84 may attenuate 5-FU-induced cell death. The results of clinical research showed that the onset of severe oral mucositis was reduced by intervention of professional oral health care for esophagus cancer patients during chemotherapy. TJ-84 acted as a drug effect on periodontopathogenic bacteria, F. nucleatum and C. rectus and significantly decreased a number of these bacteria in addition to reduced gingival inflammation. These findings suggest that it may be useful for cancer patients in supportive cure by oral health management applied with Kampo medicine.

Free Research Field

予防歯科学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi