2014 Fiscal Year Final Research Report
Investigation and model preparation of tropical area-specific endemic neurodegenerative diseases
Project/Area Number |
24406004
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Drug development chemistry
|
Research Institution | Hiroshima University |
Principal Investigator |
KOTAKE Yaichiro 広島大学, 大学院医歯薬保健学研究院, 准教授 (20335649)
|
Co-Investigator(Kenkyū-buntansha) |
OHTA Shigeru 広島大学, 大学院医歯薬保健学研究院, 教授 (60160503)
MURATA Miho 国立精神神経センター, 病院(神経内科診療部), 部長 (30282643)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 国際研究者交流 / 神経変性疾患 / 熱帯地域 / パーキンソン病 / P糖タンパク質 |
Outline of Final Research Achievements |
This study is aimed to investigate the relationship between tropical area-specific endemic neurodegenerative diseases and their dietary habits. We performed a field survey about the distribution of Annona Muricata, the occurrence of the disease, and their dietary habits, especially in Guam. We clarified that O,O-dimethylcoclaurine (DMC) involved in the Annona Muricata inhibits P-glycoprotein (P-gp) and is also a substrate of P-gp. DMC exerted weak neurotoxicty in in vivo. Taken together, it is suggested that DMC might be one of the candidate substances related to the disease.
|
Free Research Field |
神経毒性学
|