Investigation and model preparation of tropical area-specific endemic neurodegenerative diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24406004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Drug development chemistry
• Research Institution: Hiroshima University
• Principal Investigator: KOTAKE Yaichiro 広島大学, 大学院医歯薬保健学研究院, 准教授 (20335649)
• Co-Investigator(Kenkyū-buntansha): OHTA Shigeru 広島大学, 大学院医歯薬保健学研究院, 教授 (60160503) ; MURATA Miho 国立精神神経センター, 病院(神経内科診療部), 部長 (30282643)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 国際研究者交流 / 神経変性疾患 / 熱帯地域 / パーキンソン病 / P糖タンパク質

Outline of Final Research Achievements

This study is aimed to investigate the relationship between tropical area-specific endemic neurodegenerative diseases and their dietary habits. We performed a field survey about the distribution of Annona Muricata, the occurrence of the disease, and their dietary habits, especially in Guam. We clarified that O,O-dimethylcoclaurine (DMC) involved in the Annona Muricata inhibits P-glycoprotein (P-gp) and is also a substrate of P-gp. DMC exerted weak neurotoxicty in in vivo. Taken together, it is suggested that DMC might be one of the candidate substances related to the disease.

Free Research Field

神経毒性学