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2014 Fiscal Year Final Research Report

Investigation and model preparation of tropical area-specific endemic neurodegenerative diseases

Research Project

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Project/Area Number 24406004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Drug development chemistry
Research InstitutionHiroshima University

Principal Investigator

KOTAKE Yaichiro  広島大学, 大学院医歯薬保健学研究院, 准教授 (20335649)

Co-Investigator(Kenkyū-buntansha) OHTA Shigeru  広島大学, 大学院医歯薬保健学研究院, 教授 (60160503)
MURATA Miho  国立精神神経センター, 病院(神経内科診療部), 部長 (30282643)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords国際研究者交流 / 神経変性疾患 / 熱帯地域 / パーキンソン病 / P糖タンパク質
Outline of Final Research Achievements

This study is aimed to investigate the relationship between tropical area-specific endemic neurodegenerative diseases and their dietary habits. We performed a field survey about the distribution of Annona Muricata, the occurrence of the disease, and their dietary habits, especially in Guam. We clarified that O,O-dimethylcoclaurine (DMC) involved in the Annona Muricata inhibits P-glycoprotein (P-gp) and is also a substrate of P-gp. DMC exerted weak neurotoxicty in in vivo. Taken together, it is suggested that DMC might be one of the candidate substances related to the disease.

Free Research Field

神経毒性学

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Published: 2016-06-03  

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