2013 Fiscal Year Annual Research Report
南アジアと日本における若年冠動脈疾患患者の新しい危険因子の同定とその予防法の開発
| Project/Area Number |
24406026
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| Section | 海外学術 |
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| Research Institution | 独立行政法人国立国際医療研究センター |
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Principal Investigator |
諸井 雅男 独立行政法人国立国際医療研究センター, その他部局等, その他 (30256721)
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| Co-Investigator(Kenkyū-buntansha) |
水谷 太郎 筑波大学, 医学医療系, 教授 (80181890)
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 南アジア / 若年冠動脈疾患 / 危険因子 / 予防法 |
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| Research Abstract |
Through analysis of prospective observational study and case-control study, we found mean age of younger patients of acute coronary syndrome (ACS) in Bangladesh was 43.25 ± 0.27 years. Among our young study subjects having ACS, STEMI ACS was 54%, non-STEMI ACS was 6% and unstable angina was 28%. Mean age of male and female ACS patients was same. Prevalence of ACS was higher in male subjects compared to female subjects. There was no significant difference in rural and urban prevalence of ACS in Bangladesh. The prevalence of metabolic syndrome in male and female ACS patients was 26.56% vs. 45.71%. The prevalence of important cardio metabolic risk factors in young ACS patients in Bangladesh are: diabetes (29.89%); hypertension (39.27%); low HDL (51.77%); elevated triglyceride (44.29%). 16.3% young ACS patients in Bangladesh are overweight whereas 3.26% patients are obese. 26% of young ACS patients in Bangladesh have sedentary life style. 58.7% young ACS patients in Bangladesh are current smoker. No (0); one (1); two (2); three (3) or more than three metabolic abnormality is present in 11%; 28%; 30% as well as in 31% young ACS patients in Bangladesh, respectively. In young STEMI ACS patients in Bangladesh, diabetes is a highly prevalent risk factor compared to older ACS patients with STEMI. For non-STEMI myocardial infarction, hypertension appears to be the main risk factor in young Bangladeshi population. Appropriate strategies are needed for the early detection and treatment of cardio metabolic risk factors to prevent coronary artery disease progression in Bangladesh.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
This year we will continue the rest of the case control and cross sectional study that already started. In the case control study, we are determining cardiovascular risk factors in young patients with coronary heart disease (CHD) in Bangladesh. Successive consenting patients <45 yr with an acute coronary event or recent diagnosis of CHD are enrolled (cases, n=200) especially from the prospective observational study. Age- and gender-matched subjects with no clinical evidence of CHD are recruited as controls (n=200) especially from the people who come to hospital for general health checkup. Besides, we already performed a part of cross sectional study in last two years. This year also we will continue to conduct a cross sectional study design in population to find out the prevalence of conventional and emerging risk factors of CHD in rural Bangladeshi population in Dhaka and Rajshahi divisions. Consistent to our other studies on non-communicable diseases, we recruit the study population aged (15-75 years of age) so that our pilot data can be compared. A multi-stage random sampling method is used to recruit the study participants. This year we will continue socio demographic assessment, clinical, biochemical and functional assessment, advanced biomarkers measurement, environmental factors association determination, data analysis and interpretation, compare the data of Bangladesh with other South Asian countries, compare the data with Japanese population, planning the health policy reformulation for South Asian countries including Bangladesh.
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| Strategy for Future Research Activity |
This year we will continue the rest of the case control and cross sectional study that already started. In the case control study, we are determining cardiovascular risk factors in young patients with coronary heart disease (CHD) in Bangladesh. Successive consenting patients <45 yr with an acute coronary event or recent diagnosis of CHD are enrolled (cases, n=200) especially from the prospective observational study. Age- and gender-matched subjects with no clinical evidence of CHD are recruited as controls (n=200) especially from the people who come to hospital for general health checkup. Besides, we already performed a part of cross sectional study in last two years. This year also we will continue to conduct a cross sectional study design in population to find out the prevalence of conventional and emerging risk factors of CHD in rural Bangladeshi population in Dhaka and Rajshahi divisions. Consistent to our other studies on non-communicable diseases, we recruit the study population aged (15-75 years of age) so that our pilot data can be compared. A multi-stage random sampling method is used to recruit the study participants. This year we will continue socio demographic assessment, clinical, biochemical and functional assessment, advanced biomarkers measurement, environmental factors association determination, data analysis and interpretation, compare the data of Bangladesh with other South Asian countries, compare the data with Japanese population, planning the health policy reformulation for South Asian countries including Bangladesh.
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| Expenditure Plans for the Next FY Research Funding |
Last year we did not measure the expensive biomarkers from this grant money, we had some donations from local Bangladesh to buy some expensive re-agents.
This year we will use the saved money from last year to measure more expensive biomarkers than planned originally.
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[Journal Article] Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis.2014
Author(s)
Morooka M, Moroi M, Uno K, Ito K, Wu J, Nakagawa T, Kubota K, Minamimoto R, Miyata Y, Okasaki M, Okazaki O, Yamada Y, Yamaguchi T, Hiroe M.
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Journal Title
EJNMMI Res.
Volume: 2;4(1)
Pages: 1
DOI
Peer Reviewed
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[Journal Article] Screening for gestational diabetes mellitus and its prevalence in Bangladesh.2014
Author(s)
Jesmin S, Akter S, Akashi H, Mamun AA, Rahman MA, Islam MM, Sohael F, Okazaki O, Moroi M, Kawano S, Mizutani T.
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Journal Title
Diabetes Research and Clinical Practice
Volume: 103 (1)
Pages: 57-62
DOI
Peer Reviewed
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[Journal Article] Metabolic syndrome among pre- and post-menopausal rural women in Bangladesh: result from a population-based study.2013
Author(s)
Jesmin S, Islam AS, Akter S, Islam MM, Sultana SN, Yamaguchi N, Okazaki O, Moroi M, Hiroe M, Kimura S, Watanabe T, Saturo K, Mizutani T.
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Journal Title
BMC Res Notes
Volume: 18;6(1)
Pages: 157-164
DOI
Peer Reviewed
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[Journal Article] Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women.2013
Author(s)
Jesmin S, Akter S, Rahman MM, Islam MM, Islam AM, Sultana SN, Mowa CN, Yamaguchi N, Okazaki O, Satoru K, Kimura S, Hiroe M, Mizutani T, Moroi M.
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Journal Title
Thrombosis and Haemostasis
Volume: 109(4)
Pages: 696-705
DOI
Peer Reviewed
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[Journal Article] Screening for gestational diabetes mellitus in Bogra sadar, Bogra Bangladesh.2013
Author(s)
Jesmin S, Rahman A, Sohael F, Akter S, Islam MM, Khatun MT, Sultana SN, Mamun AA, Akashi H, Habib AKMA.
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Journal Title
Journal of Shaheed Ziaur Rahman Medical College
Volume: 20
Pages: 19-23
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[Presentation] Potential association between circulatory level of endothelin-1 and metabolic syndrome in Bangladeshi rural women: a population-based cross-sectional study2013
Author(s)
Islam M, Jesmin S, Rahman A, Habib AKMA, Akter S, Shimojo N, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Year and Date
20130908-20130911
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[Presentation] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross sectional study in rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Year and Date
20130908-20130911
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[Presentation] Assessment of circulatory endothelin-1 level among pre- and post-menopausal rural women in Bangladesh: result from a population-based study2013
Author(s)
Khatutn T, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Year and Date
20130908-20130911
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[Presentation] elective endothelin (ET)-A receptor antagonist and dual ET-A/B receptor antagonist are effective in preventing the decrease in VEGF signaling and inadequate coronary collateral development in the diabetic hearts2013
Author(s)
Miyauchi Y, Jesmin S, Shimojo N, Maeda S, Sakai S, Yokota T, Zaedi S, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Year and Date
20130908-20130911
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[Presentation] Endothelin antagonism and diabetic erectile dysfunction: Changes in VEGF and NO in type I diabetic penis and effects of endothelin antagonism2013
Author(s)
Zaedi S, Jesmin S, Shimojo N, Sakai S, Maeda S, Miyauchi Y, Yokota T, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Year and Date
20130908-20130911
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[Presentation] Potential association between disrupted VEGF angiogenic signaling and metabolic syndrome in Bangladeshi rural women,2013
Author(s)
Jesmin S, Akter S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa
Place of Presentation
東京
Year and Date
20130629-20130629
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[Presentation] Comprehensive assessment of metabolic syndrome prevalence and its components among rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa
Place of Presentation
東京
Year and Date
20130629-20130629
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[Presentation] The predictors of cardiovascular events in hemodialysis patients who unserwent stress myocardial perfusion imaging.2013
Author(s)
Furuhashi T, Moroi M, Joki N, Hase H, Minagawa M, Masai H, Kunimasa T, Fukuda H, Sugi K
Organizer
ICNC 11, Nuclear Cardiology and Cardiac CT.
Place of Presentation
Berlin, Germany
Year and Date
20130507-20130507
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[Book] Diabetes Mellitus and Human Health Care - A Holistic Approach to Diagnosis and Treatment Chapter 12: Development of Therapeutic Strategy to Restore Coronary Microcirculation and VEGF Signaling Cascade in Diabetes: A Novel Approach to Prevent Cardiac Complication in Diabetes.2014
Author(s)
Jesmin S, Rahman A, Mamun AA, Sohael F, Akter S, Iwashima Y, Shimojo N, Yamaguchi N, Hiroe M, Mizutani T, Moroi M.
Total Pages
504
Publisher
Apple Academic Press Inc.
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