2014 Fiscal Year Annual Research Report
南アジアと日本における若年冠動脈疾患患者の新しい危険因子の同定とその予防法の開発
| Project/Area Number |
24406026
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
諸井 雅男 独立行政法人国立国際医療研究センター, その他部局等, その他 (30256721)
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| Co-Investigator(Kenkyū-buntansha) |
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
水谷 太郎 筑波大学, 医学医療系, 教授 (80181890)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 南アジア / 若年冠動脈 / 危険因子 / 予防法 |
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| Outline of Annual Research Achievements |
We have completed three years of this project, with the completion of prospective observational study, case control study and a cross sectional study in Bangladesh on coronary artery disease. Through cross sectional study, we found prevalence of individual risk factors studied was as follows: findings from STEPS1 (behavioral risk factors); 86.9% unhealthy diets, 53.5% tobacco use, 21.7% smoking, 41.4% physical inactivity, 0.7% alcohol consumption; SETPS 2 (physical risk factors): 28.5% elevated blood pressure, 24.1% overweight, 19.7% abdominal obesity; STEPS3 (cardio metabolic risk factors): 10.2% elevated fasting blood glucose, 65.7% low HDL cholesterol, 28.0% raised total cholesterol, 33.8% raised triglyceride. From the prospective observational study and case control study, % of acute coronary syndrome (ACS) was higher in male compared to female. The prevalence of important cardio metabolic risk factors in young ACS patients in Bangladesh is: diabetes (29.89%); hypertension (39.27%); low HDL (51.77%); elevated triglyceride (44.29%); metabolic syndrome (36.13%); overweight (16.3%); obesity (3.26%). 58.7% young ACS patients in Bangladesh are current smoker. No (0); one (1); two (2); three (3) or more than three metabolic abnormality is present in 11%; 28%; 30% as well as in 31% young ACS patients in Bangladesh, respectively. In young STEMI ACS patients in Bangladesh, diabetes is a highly prevalent risk factor compared to the older ACS patients with STEMI. For non-STEMI myocardial infarction, hypertension appears to be the main risk factor in young Bangladeshi population.
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| Research Progress Status |
26年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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| Causes of Carryover |
26年度が最終年度であるため、記入しない。
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| Expenditure Plan for Carryover Budget |
26年度が最終年度であるため、記入しない。
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[Journal Article] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women.2015
Author(s)
Akter S, Jesmin S, Iwashima Y, Hideaki S, Rahman MA, Islam MM, Moroi M, Shimojo N, Yamaguchi N, Miyauchi T, Kawano S, Mizutani T, Kawano Y.
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Journal Title
Hypertens Res.
Volume: 38(3)
Pages: 208-212
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Assessment of circulatory levels of endothelin-1 in diabetic subjects screened through a cross sectional study from rural women in Bangladesh.2015
Author(s)
Rahman MA, Jesmin S, Mowa CN, Sohael F, Kamiyama J, Habib AKMA, Shimojo N, Islam MM, Moroi M, Okazaki O, Yamaguchi N, Kawano S, Mizutani T, Iwashima Y.
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Journal Title
International Journal of Diabetes and Clinical Research.
Volume: 2
Pages: 1
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Assessment of circulatory endothelin-1 level among pre and post-menopausal rural women in Bangladesh: result from a population-based study.2015
Author(s)
Khatun T, Jesmin S, Yamaguchi N, Kamiyama J, Akter S, Sultana SN, Islam M, Okazaki O, Kawano S, Akashi H, Mizutani T, Miyauchi T, Rahman A, Habib AKMA.
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Journal Title
Annals of Vascular Medicine & Research.
Volume: 2
Pages: 1014
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Myocardial perfusion imaging for predicting cardiac events in Japanese patients with advanced chronic kidney disease: 1-year interim report of the J-ACCESS 3 investigation2014
Author(s)
Joki N, Hase H, Kawano Y, Nakamura S, Nakajima K, Hatta T, Nishimura S, Moroi M, Nakagawa S, Kasai T, Kusuoka H, Takeishi Y, Momose M, Takehana K, Nanasato M, Yoda S, Nishina H, Matsumoto N, Nishimura T.
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Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 41(9)
Pages: 1701-1709
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats.2014
Author(s)
Miyauchi Y, Jesmin S, Sakai S, Kamiyama J, Shimojo N, Rahman A, Islam M, Zaedi S, Maeda S, Maruyama H, Mizutani T, Homma S, Aonuma K, Miyauchi T.
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Journal Title
Life Sciences
Volume: 111(1-2)
Pages: 6-11
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Endothelin-1 and metabolic syndrome in Bangladeshi rural women.2014
Author(s)
Islam MM, Jesmin S, Akter S, Mowa CN, Sakuramoto H, Chowdhury SR, Rahman A, Habib AKMA, Okazaki O, Shimojo N, Miyauchi T, Kawano S, Mizutani T.
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Journal Title
Annals of Vascular Medicine & Research.
Volume: 1
Pages: 1008
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] National profile of non-communicable disese risk factors in Bangladesh2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Shimojo N, Okazaki O, Kawano S.
Organizer
Celebration of 2nd Public Health Foundation Day & Scientific Seminar
Place of Presentation
Dhaka, Bangladesh
Year and Date
2014-12-07 – 2014-12-08
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[Presentation] Prevalence of metabolic syndrome components among early age oneset acute coronary syndrome patients in Bangladesh2014
Author(s)
Rahman MA, Jesmin S, Habib AKMA,Haider S, Khan Amiruzzaman, Islam MM, Khatun MT, Sultana SN, Sultana SN, Sohael F, Moroi M.
Organizer
Celebration of 2nd Public Health Foundation Day & Scientific Seminar
Place of Presentation
Dhaka, Bangladesh
Year and Date
2014-12-07 – 2014-12-08
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[Presentation] Alteration of VEGF angiogenic signaling system in metabolic syndrome: findings from a study conducted in rural Bangladeshi women2014
Author(s)
Jesmin S, Mamun AA, Rahman MA, Islam MM, Akter S, Rahman MM, Sultana SN, Yamaguchi N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
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[Presentation] National profile of non-communicable disease risk factors in Bangladesh2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Shimojo N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
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[Presentation] Innovation of a potential novel biomarker to predict the risk of developing diabetes in postmenopausal women based on the estrogen-VEGF axis2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Islam MM, Khatun T, Sultana SN, Moroi M, Yamaguchi N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
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[Presentation] Metabolic syndrome prevalence and its components among rural Bangladeshi women2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Moroi M, Okazaki O, Kawano S.
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
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[Presentation] Prevalence of metabolic syndrome components among early age onset acute coronary syndrome patients in Bangladesh2014
Author(s)
Jesmin S, Mamun AA, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Okazaki O, Moroi M, Kawano S.
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
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[Presentation] Assessment of circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study in rural Bangladeshi women2014
Author(s)
Jesmin S, Iwashima Y, Islam MM, Rahman MA, Akter S, Hideaki S, Shimojo N, Moroi M, Yamaguchi N, Okazaki O, Kawano S, Kawano Y
Organizer
The 37th Annual Scientific Meeting of the Japanese Society of Hypertension
Place of Presentation
横浜
Year and Date
2014-10-19 – 2014-10-19
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[Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh2014
Author(s)
esmin S, Iwashima Y, Islam MM, Rahman MA, Habib AKMA, Shimojo N, Moroi M, Yamaguchi N, Okazaki O, Kawano S, Kawano Y
Organizer
The 37th Annual Scientific Meeting of the Japanese Society of Hypertension
Place of Presentation
横浜
Year and Date
2014-10-19 – 2014-10-19
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[Presentation] National burden of non-communicable disease risk factors in Bangladesh2014
Author(s)
esmin S, Rahman MA, Kamiyama J, Habib AKMA, Islam MM, Sohael F, Khatun T, Sultana SN, Shimojo N, Okazaki O, Moroi M, Yamaguchi N, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] VEGF angiogenic signaling system in metabolic syndrome: Findings from a cross sectional study conducted in rural Bangladeshi women2014
Author(s)
Jesmin S, Rahman MA, Islam MM, Akter S, Rahman MM, Sultana SN, Yamaguchi N, Shimojo N, Okazaki O, Moroi M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] Higher level of endothelin-1 in hypertensive Rural Women in Bangladesh. Results of a Community based cross-sectional study2014
Author(s)
Rahman MA, Jesmin S, Iwashima Y, Ali A, Akter S, Khan A, Islam MM, Moroi M, Yamaguchi N, Shimojo N, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] Prevalence of Metabolic Syndrome Components Among Early Age onset Acute Coronary Syndrome Patients in Bangladesh2014
Author(s)
Rahman MA, Jesmin S, Habib AKMA, Haider S, Khan A, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Shimojo N, Kawano S, Moroi M.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] An analysis of association between circulatory level of endothelin-1 and metabolic syndrome in Bangladeshi rural women2014
Author(s)
Rahman MA, Jesmin S, Islam MM, Habib AKMA, Akter S, Shimojo N, Sohael F, Zaedi S, Yamaguchi N, Moroi M, Okazaki O, Hiroe M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] Metabolic syndrome among rural Bangladeshi women2014
Author(s)
Rahman MA, Jesmin S, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Moroi M, Okazaki O, Hiroe M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
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[Presentation] アピキサバン投与により左房内血栓が消失した頻脈性心房細動によるうっ血性心不全の一例2014
Author(s)
能登辰徳, 榎本喜成, 松田 剛, 牧野健治, 山崎健司, 柴 昌徳, 飯島雷輔, 原 英彦, 野呂眞人, 諸井雅男, 中村正人, 杉 薫
Organizer
第233回日本循環器学会関東甲信越地方会
Place of Presentation
東京
Year and Date
2014-09-06 – 2014-09-06
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[Book] Diabetes Mellitus and Human Health Care2014
Author(s)
1.Jesmin S, Mamun AA, Rahman A, Akter S, Iwashima Y, Shimojo N, Yamaguchi N, Hiroe M, Mizutani T, Moroi M（分担）
Total Pages
520
Publisher
Apple Academic press, Canada
