Relationship between periodontal infection and HIV infection in Kenya using simultaneous microsphere-based multiplex assays

2014 Fiscal Year Final Research Report

• Project/Area Number: 24406034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: NAKAYAMA Koji 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80150473)
• Co-Investigator(Kenkyū-buntansha): KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907) ; HARA Yoshitaka 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100) ; FUJII Yoshito 長崎大学, 熱帯医学研究所, 助教 (10404237)
• Co-Investigator(Renkei-kenkyūsha): TSUKUBA Tomoko (KADOWAKI Tomoko) 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70336080)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯周病原細菌感染 / HIVに対する抗体価 / エイズ

Outline of Final Research Achievements

We investigated the relationship between levels of plasma antibodies against 4 bacterial species of periodontal pathogens and a level of plasma antibody against HIV in 242 blood samples randomly collected from the general population older than 20 years in Mbita region of Kenya. As a result, we found that groups with higher levels of anti-HIV showed lower levels of anti-periodontal pathogens. This tendency was observed in the relationship between anti-HIV and anti-other pathogens. These results indicate that general suppression of antibody production by HIV infection affects production of anti-periodontal pathogens antibodies.

Free Research Field

口腔病原微生物学