Studies on the influence of brain and neurons of mutation of synaptic cell adhesion molecule protein, Cadm1 using autism mouse models.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24500386
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Jichi Medical University
• Principal Investigator: Jimbo Eriko (藤田恵理子) 自治医科大学, 医学部, 講師 (20291651)
• Co-Investigator(Kenkyū-buntansha): MOMOI Takashi 東京医科大学, 医学部, 客員教授 (40143507)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: シナプス接着分子 / Cadm1 / 変異

Outline of Final Research Achievements

Autism spectrum disorder is the neurodevelopmental disorder, characterized by impaired social interactions, social communication impairments. It seems that a combination of genetic and environmental, factors contribute to the pathogenesis of autism.Most candidate genes for conferring susceptibility to autism are known to play a role in brain development.
We previously found missense mutations, in the gene-encoding CADM1 in patients. In this study, we aimed to make clear the molecular mechanisms of Autism, and focus the Cadm1 gene and do some experiment about the protein-complex included Cadm1 using the mice of Cadm1-KO, Cadm1-KI and Cadm1-GFP-Tg.
As the results, we found that the mutated CADM1 affected the synaptogenesis, the neuronal maturation, the formation of CADM1-molecular complex.

Free Research Field

神経分子生物学