The onset mechanism of neurodegenerative diseases caused by mutation in the genes encoding lamins and nuclear lamina associated proteins.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kansai Medical University
• Principal Investigator: TAKAMORI Yasuharu 関西医科大学, 医学部, 助教 (50309233)
• Research Collaborator: YAMADA Hisao 関西医科大学, 医学部, 教授 (00142373) ; WAKABAYASHI Taketoshi 関西医科大学, 医学部, 准教授 (90302421) ; MORI Tetsuji 関西医科大学, 医学部, 准教授 (30285043) ; WADA Yukie (HIRAHARA Yukie) 関西医科大学, 医学部, 助教 (70457969) ; KUROKAWA Kiyoshi 大阪国際大学, 人間科学部, 教授 (40215083) ; KOSAKA Jun 岡山大学, 医歯(薬)学総合研究科, 准教授 (40243216) ; KOIKE Taro 関西医科大学, 医学部
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経科学 / 細胞・組織 / 蛋白質 / 脳・神経 / 発生・分化 / 核膜 / 核ラミナ / ラミン

Outline of Final Research Achievements

Mutations in genes encoding lamins and nuclear lamina associated proteins cause diverse human congenital diseases including neurodegenerative disorders. In this study, we investigated the distribution of lamin and nuclear lamina associated proteins in the central nervous system using immunohistochemical method to reveal the onset mechanism of these neurodegenerative diseases. We have revealed the expression patterns for lamin subtypes during neurogenesis in the adult ferret brain, and the composition of lamin subtypes in glial cell types as well as the composition of nuclear lamina associated proteins in neural cell types in the adult rat brain.

Free Research Field

細胞生物学