Pathological analysis and standardization of iron-induced epileptic lesions

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: ARAI Nobutaka 公益財団法人東京都医学総合研究所, 病院等連携研究センター, 副所長 (10167984)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: てんかん / 鉄 / 脳外科治療 / 焦点病理診断 / 海綿状血管腫

Outline of Final Research Achievements

This study clarified a form of the astrocytic abnormality (named foamy spheroid body), probably induced by iron composure, with abundant hemosiderin pigments in cases of cavernous hemangioma and post-traumatic lesions. In addition, this study reveled that the much iron composure around the lesions got the epileptogenic nature In the hippocampus of mesial temporal lobe epilepsy after head injuries, many iron-deposits appeared unexpectedly. It was thought that such knowledge would contribute for strategic planning of the epilepsy surgery treatment.

Free Research Field

神経病理学