Identification of genes for ulcerative colitis utilizing SAM mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500487
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Shinshu University
• Principal Investigator: MORI Masayuki 信州大学, 学術研究院医学系, 准教授 (60273190)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 潰瘍性大腸炎 / マウス / Abcb1a / 遺伝子

Outline of Final Research Achievements

It was found that development of ulcerative colitis under the compromised Abcb1a function is influenced by modifier genes located on chromosomes 16 and 13 by using SAMP1 and FVB/N mouse strains that have a loss-of-function mutation in the Abcb1a gene, which functions in the exclusion of a wide range of drugs from the cell. It was also revealed that one of the modifier genes is located in the interval of approximately 7 Mb on chromosome 16. Furthermore, a missense nucleotide substitution polymorphism in the Ifnar1 gene was discovered between the two mouse strains that the SAM strains. However, it was not clear if the polymorphism is actually involved in the determination of development of ulcerative colitis under the compromised Abcb1a function.

Free Research Field

実験動物学