Establishment of bio-imaging system for detecting neural stem cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500498
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: HAKAMATA YOJI 日本獣医生命科学大学, 獣医学部, 教授 (00218380)
• Co-Investigator(Kenkyū-buntansha): FUJISAWA Masahiko 日本獣医生命科学大学, 獣医学部, 講師 (10508873)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経再生 / 再生医療 / 間葉系幹細胞 / トランスジェニック動物 / 脳虚血 / 神経細胞死

Outline of Final Research Achievements

To establish the bio-imaging system for detecting neural stem cell after transplantation, we isolated cell marker expressed transgenic rats and normal gerbils mesenchymal stem cells (MSCs) cell from each bone marrows. We also evaluated the neuroprotective effects of labeled MSCs using the transient cerebral ischemia gerbil model. This result demonstrated that MSCs can accumulate in injured areas presumably due to chemokine activities and contribute to neuroprotection. Bio-imaging system with cell marker labeling by quantum dots and transgenic animal technology is very useful tool for detecting neural stem cell.

Free Research Field

神経病理