2014 Fiscal Year Final Research Report
Study of the bone metabolism in diabetes and of improvement by the exercise using newly-introduced diabetes model
| Project/Area Number |
24500848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Nobuo 金沢大学, 環日本海域環境研究センター, 准教授 (60242476)
KOGAYA Yasutoku 朝日大学, 歯学部, 准教授 (30076046)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖尿病 / 骨代謝 / 糖尿病状態キンギョモデル / アロキサン / 再生ウロコ |
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| Outline of Final Research Achievements |
We investigated the cause of the increased fracture rate in diabetes patients through analyses of bone metabolism and the properties of bone matrix protein by using goldfish scales as a bone model of hyperglycemia that is induced by an alloxan injection. The results showed that the marker enzyme activities in the scale osteoblasts and osteoclasts did not significantly differ between hyperglycemic and euglycemic goldfish. This suggests that hyperglycemia has minimal effect on bone metabolism. Moreover, we found that the formation of non-enzymatic cross-linked collagen, which has more than 3 times the molecular weight of a single fiber, was significantly increased in the scale-bone matrix of the hyperglycemic goldfish.
Our results suggest that the increased fracture rate in diabetes patients is mostly due to the loss of flexibility of the collagen fibers, which is mediated by the excessive formation of non-enzymatic cross-linked collagen in the bone matrix.
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| Free Research Field |
病態検査学
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