Functional analysis of the lipid nourishment controlling the development of the brain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nayoro City University
• Principal Investigator: YAMAMOTO TATSURO 名寄市立大学, 保健福祉学部, 講師 (90379389)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Naomichi 静岡大学, 農学部, 教授 (10341079) ; YAMAMOTO Ayako 名寄市立大学, 保健福祉学部, 研究員 (80414134)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂質栄養 / 脳 / 神経細胞 / グリア細胞

Outline of Final Research Achievements

In the fetus and infant period, those nutrition depends on the nutritional state of maternal diet. Because brains develop well at these periods, it is affected by the nourishment state of the maternal diet. It is thought that the lipid, which is the component of the cell, affects the development of the brain, but the detailed function in the development of the brain at the fetus and infant period of the lipid nourishment is unclear. In this study, to elucidate a role of the lipid nourishment in the development of the brain of a fetus and infant brain, we performed morphological and behavioral analyses of the pups form the maternal that fed the n-3 polyunsaturated fatty acid deficient diet. As a result, we observed astrocyte decrease in the cerebral neocorex and emotional instability in the n-3 polyunsaturated fatty acid deficient pups.

Free Research Field

神経解剖学