A combination therapy with hyperthermia and immunotherapy using dextran magnetic nanoparticle for esophageal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Chiba University
• Principal Investigator: AKUTSU Yasunori 千葉大学, 医学(系)研究科(研究院), 講師 (00375677)
• Co-Investigator(Kenkyū-buntansha): TAMURA Yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 免疫療法 / 温熱療法 / 樹状細胞 / ヒートショックプロテイン / 食道癌 / 扁平上皮癌

Outline of Final Research Achievements

(1)We developed a combination therapy with hyperthermia and direct intratumoral administration of dendritic cells. When compared with dendriti cell therapy alone, a combination therapy showed strong antitumor effect. Furtheremore, we elucidated the molecular mechanism. The expression of heat shock protein was enhanced by hyperthermia.(2)We also developed ICG-Liposome as an enhancer of PDT. ICG-Liposome was accumulated in the tumor by EPR effect. By near infrared, tumor specific heating was possible.

Free Research Field

腫瘍免疫