Characterization of energy metabolism in solid tumors by PET

2015 Fiscal Year Final Research Report

• Project/Area Number: 24501348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Furukawa Takako 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (00221557)
• Co-Investigator(Renkei-kenkyūsha): JIN Zhao-hui (国立研究開発法人)放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (70324150)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 腫瘍 / 代謝 / FDG / FLT / 酢酸 / グルタミン

Outline of Final Research Achievements

In this study, to examine the　relation between the two different radiopharmaceuticals targeting cancermetabolosm, we compared tumor accumulation and intratumoral distribution of FDG, FLT, acetate and glutamine, administering two radiotracers with different half-lives in combination, [18F]FLT and [14C]FDG for example, into tumor bearing mice. In the double tracer biodistribution study, positive correlation was only observed between FDG and glutamine, and FLT and acetate. The intratumoral distributions of the two tracers in the above two combinations showed similarity, but in the other combinations the two tracers often showed different pattern. From our observation, accumulation and intratumoral distribution of the four PET pharmaceuticals or tracers, FDG, FLT, acetate and glutamine, could be different, although they are all supposed to reflect tumor cell proliferation. Some caution may be necessary when we are interpreting their tumor accumulation.

Free Research Field

放射線医学