2014 Fiscal Year Final Research Report
Understanding the molecular functions of the condensin complex in chromosome condensation
| Project/Area Number |
24570006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUTANI Takashi 東京大学, 分子細胞生物学研究所, 助教 (30401524)
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| Research Collaborator |
SAKATA Toyonori
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 染色体 / 染色体凝縮 / 染色体分配 / 転写 / 分裂酵母 / ChIP-seq法 / 染色体高次構造 |
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| Outline of Final Research Achievements |
The condensin plays an important role in shaping genomic DNA into compact, rod-like “condensed” chromosomes, and is required for faithful inheritance of genetic material. In this study, I aimed to reveal the molecular function of condensin in condensation through high resolution mapping of condensin binding locations in condensed chromosomes. I found that condensin targets and rewinds unwound DNA structure created by transcription during mitosis, thereby contributing to chromosome condensation.
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| Free Research Field |
ゲノム情報・構造学
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