2015 Fiscal Year Final Research Report
Structure and mechanism of bacterial flagella rod
| Project/Area Number |
24570132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SAIJO-HAMANO Yumiko (濱野由見子) 大阪大学, 生命機能研究科, 特任助教 (00444513)
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| Co-Investigator(Renkei-kenkyūsha) |
IMADA Katsumi 大阪大学, 大学院理学研究科, 教授 (40346143)
KATO Takayuki 大阪大学, 大学院生命機能研究科, 助教 (20423155)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 結晶構造解析 / 細菌べん毛 / ナノマシン |
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| Outline of Final Research Achievements |
Bacterial flagellum is a highly efficient nano-machine rotating at high speed, 300 rpm/sec if Salmonella, in viscous environments. The rod of the bacterial flagellum acts as the drive shaft to enable the high-speed rotation. FlgG is the protein to constructs the distal rod which is a major part of the rod. We revealed the molecular model at 2 angstrom resolution of a core fragment of FlgG by X-ray crystal structure analysis. Furthermore we constructed the distal rod structure based on this FlgG model to fit to cryo-EM density map.
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| Free Research Field |
生物物理
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