2014 Fiscal Year Final Research Report
Basic studies of immunoligocal function using sphingolipid-deficient mice
| Project/Area Number |
24570145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | スフィンゴ脂質 / 遺伝子改変動物 / モデルマウス |
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| Outline of Final Research Achievements |
T cell specific deletion using gene deficient mice of sphingolipids demonstrated the complete loss of them in peripheral blood stream. Previous studies demonstrated that GM3 knockout mice showed rheumatism become early onset and aggravated. The total deletion of sphingolipids and GM3, one molecule of sphingolipids showed little difference. On the other hand, a remarkable difference was observed in the colitis model mice. This suggests that amount of ceramide and ceramide-derivatives in cytoplasm participate colitis resistant phenotype of sphingolipids-dificient mice.
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| Free Research Field |
生物学
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