2014 Fiscal Year Final Research Report
Functional analysis of N-glycan on integrin alpha5beta1 for supramolecular assembly and cell proliferation
| Project/Area Number |
24570169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
ISAJI Tomoya 東北薬科大学, 薬学部, 助教 (80433514)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | インテグリン / 接着 / 細胞増殖 / 超分子複合体 |
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| Outline of Final Research Achievements |
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signaling pathways. Here we analyzed whether N-glycosylation on integrin involved cell proliferation and supramolecular assembly. We identified specific N-glycosylation sites regulating cell prolification and supramolecular assembly. Furthermore, we found that Golgi phosphoprotein 3 (GOLPH3) regulates an efficient synthesis of N-glycosylation and cell migration.
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| Free Research Field |
糖鎖生物学
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