2014 Fiscal Year Final Research Report
Development and analyses of integrated networks for cellular function predictions
| Project/Area Number |
24570176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 遺伝子共発現 / 蛋白質間相互作用 / 統合ネットワーク / 種間比較 / クラスター解析 |
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| Outline of Final Research Achievements |
We have more than several thousands of whole genome sequences of many divergent species, but more than half of the genes on the genomes are still uncharacterized. It is almost impossible to determine all functions of all genes by experimental procedure, and thus some computational approaches to infer some possible functions of the uncharacterized genes. In this study, we have constructed integrated networks by using RNA-seq based co-expression networks and high throughput protein-protein interaction data, and developed a method to compare the integrated networks among the species. We also developed a new clustering method and applied it to infer the cellular function of uncharacterized genes.
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| Free Research Field |
生命情報科学
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