2014 Fiscal Year Final Research Report
Molecular mechanism of endocytosis by a novel membrane-bending domain
| Project/Area Number |
24570216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
ITOH TOSHIKI 神戸大学, 学内共同利用施設等, 教授 (30313092)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJITA Kazuya 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 助教 (10457054)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | エンドサイトーシス / イノシトールリン脂質 |
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| Outline of Final Research Achievements |
It was found that human SH3YL1, which contains a novel phosphoinositide-binding domain named the SYLF domain, is involved in endocytosis of epidermal growth factor receptor. In vitro, SH3YL1 not only bound to liposomes, but also mediated interactions between liposomes that it resides, promoting aggregation of membrane vesicles. This study also succeeded in obtaining a knowledge about the positively-charged residues in the SYLF domain that participate in lipid-binding, therefore will provide a novel molecular basis of endocytosis.
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| Free Research Field |
細胞生物学
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