Physiological analysis of polyunsaturated fatty acid (PUFA) in Saccharomyces cerevisiae and its application to improving stress tolerance

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Kyoto University
• Principal Investigator: TANAKA Koichi 京都大学, (連合)農学研究科(研究院), 研究員 (90282615)
• Co-Investigator(Kenkyū-buntansha): SHIMA Jun 龍谷大学, 農学部, 教授 (00343822)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 出芽酵母 / 不飽和脂肪酸 / ストレス耐性 / バイオエタノール / 酢酸

Outline of Final Research Achievements

Lignocellulose hydrolysates contain aliphatic acids, such as acetic acid, that negatively affects the fermentation ability of S. cerevisiae. In this study, we found that the strain overexpressing HAA1 gene acquired a higher level of acetic acid tolerance. The ethanol production ability of HAA1-overexpressing strain was not influenced by acetic acid addition. We believe that this technology has the great potential to reduce bioethanol production costs.

Free Research Field

応用微生物学