Development of pro-biotic lactic acid bacteria protecting intestine from oxidation stress

2015 Fiscal Year Final Research Report

• Project/Area Number: 24580125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: NIIMURA YOUICHI 東京農業大学, 応用生物科学部, 教授 (00180563)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 乳酸菌 / プロバイオティックス / 過酸化脂質 / 過酸化脂質分解 / 活性酸素防御系 / バイオアッセイ系開発 / Caenorhabditis elegans

Outline of Final Research Achievements

In order to develop a pro-biotic lactic acid bacteria system protecting intestine from oxidation stress, lactic acid bacteria, Lactobacillus plantarum P2 was isolated from fermented food. While L. plantarum P2 exhibited high scavenging activity for environmental alkyl hydroperoxide, its activity for environmental hydorgen peroxide was not so high. Next, Pediococcus pentosaceus Be1 exhibiting high scavenging activity for environmental hydrogen peroxide was isolated from fermented vegetable. The scavenging activity for environmental peroxide in vivo of the two isolates were demonstrated by bio-assay system established with Caenorhabditis elegans Δfer-15;mev-1.

Free Research Field

応用微生物学