Study on the role of protein acetylation in translational regulation in bacteria

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580133
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: The University of Tokyo
• Principal Investigator: KOSONO Saori 東京大学, 生物生産工学研究センター, 特任准教授 (90321760)
• Co-Investigator(Renkei-kenkyūsha): DOHMAE Naoshi 理化学研究所, 環境資源科学研究センター, ユニットリーダー (00321787)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: タンパク質アセチル化 / タンパク質スクシニル化 / 翻訳制御 / EFTu / 枯草菌 / SILAC

Outline of Final Research Achievements

The role of protein acylation in translation elongation factor (EF) Tu in Bacillus subtilis was investigated. Acetylation and succinylation of Bs-EFTu was dynamically changed in response to carbon sources and growth phases. We revealed succinylation in the domain-3 negatively regulates the function of EFTu and the growth.

Free Research Field

応用微生物学