Alzheimer's disease (AD) biomarkers and new food ingredients useful for AD prevention

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: NAKAGAWA Kiyotaka 東北大学, (連合)農学研究科(研究院), 准教授 (80361145)
• Co-Investigator(Kenkyū-buntansha): MIYAZAWA Teruo 東北大学, 大学院農学研究科, 教授 (20157639)
• Co-Investigator(Renkei-kenkyūsha): ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 過酸化脂質 / miRNA / アミロイドβ / キサントフィル / アルツハイマー / バイオマーカー

Outline of Final Research Achievements

It is desired to develop biomarkers for Alzheimer's disease (AD), in order to readily start AD prevention. In this study, we found changes of phospholipid peroxides, xanthophyll and amyloid β levels in red blood cells of AD patients, indicating their usability for AD biomarkers. We obtained microRNA (miRNA) profile by analyzing AD plasma and cerebrospinal fluid, and selected potential miRNA useful for AD biomarkers. In addition, effects of food ingredients (e.g., lutein) capable of regulating these AD biomarkers were evaluated. The present results will lead to AD prevention and discovery of new food function.

Free Research Field

食品科学