2014 Fiscal Year Final Research Report
Ameriolation of adipocyte function by targeting hypoxic stress
| Project/Area Number |
24580193
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 低酸素ストレス / 脂肪細胞 |
|---|
| Outline of Final Research Achievements |
We evaluated the effect of hypoxia on the function of adipocytes and the ameliorative effect of food components on the hypoxic stress.
Hypoxic stress elicited the disruption of homeostasis of adipokine production such as reduction of adiponectin production and its oligomerization. On the other hand, some food components were capable of ameliorating this hypoxic stress. Taken together, our results provide a novel target of life style diseases that can be a useful for the development of functional food.
|
| Free Research Field |
食品機能化学
|
