2014 Fiscal Year Final Research Report
Importance of rabies virus P protein isoforms in evasion of innate immunity and pathogenicity
| Project/Area Number |
24580424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Gifu University |
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Principal Investigator |
ITO Naoto 岐阜大学, 応用生物科学部, 准教授 (20334922)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 狂犬病 |
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| Outline of Final Research Achievements |
Rabies virus P gene encodes several P protein isoforms (P1-P3) in the same reading frame. While P1 protein functions as a co-factor of viral RNA polymerase, little is known about the functions of P2 and P3 proteins. In this study, the importance of these P protein isoforms in viral pathogenicity was examined. The results obtained from experiments with viral mutants overexpressing or lacking each isoform suggest that P1 protein is mainly related to the viral neuropathogenicity.
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| Free Research Field |
人獣共通感染症学
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