Function of novel pituitary transcirption facotr PRX in the development of the pituitary galnd and teh vasculogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Meiji University
• Principal Investigator: KATO Takako 明治大学, 公私立大学の部局等, 研究員 (90445859)
• Co-Investigator(Renkei-kenkyūsha): KATO Yukio 明治大学, 農学部, 教授 (30114177)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 遺伝子 / 発現制御 / 内分泌学 / 生殖 / 細胞・組織 / 血管形成 / 分化

Outline of Final Research Achievements

This study aimed to understand role of the novel transcription factors, PRX1 and PRX2. Using generated specific antibodies for PRX1 and PRX2, we demonstrated their presence in the pituitary stem/progenitor cells and in the extrapituitary cells invaded from surrounding mesenchyme and suggest that PRX1 and PRX2 are involved in pituitary organogenesis and vasculogenesis. In addition, we have found that TtT / GF cell derived from pituitary tumors expresses PRX1 and PRX2 and exhibits stemness with expressing several stem cell markers, showing a useful model cell to clarify their functions in molecular level.

Free Research Field

分子内分泌学