2014 Fiscal Year Final Research Report
The role of proton-sensing G protein-coupled receptors on blood vessel formation and function
| Project/Area Number |
24580436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | GPCR / OGR1 / GPR4 / ゼブラフィッシュ |
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| Outline of Final Research Achievements |
OGR1, GPR4, TDGA8 and G2A are the unique GPCRs which sense extracellular proton (OGR1 family). I assume that this family participates in blood vessel formation and function under acidic condition. Zebrafish offers a useful system to analyze blood vessel formation and function. The homologous OGR1 family genes which exist in the zebrafish genome were analyzed by this research as the first step to prove the above hypothesis. The result shows that the homologous genes encode the GPCRs which sense extracellular proton like the human OGR1 family does.
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| Free Research Field |
機能生物化学
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