2014 Fiscal Year Final Research Report
Exploration of obese-related genes in cats and dogs.
| Project/Area Number |
24580467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
ISHIOKA Katsumi 日本獣医生命科学大学, 獣医学部, 准教授 (60409258)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肥満 / 犬 / 遺伝子多型 / SNP |
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| Outline of Final Research Achievements |
Obesity is a clinical problem in dogs. We explored genetic variants using genomic DNA samples collected from 141 dogs. We found 5 synonymous and 7 non-synonymous variants in the canine beta-3 adrenergic receptor gene, in which c.749C>T (p.Ser250Phe) was found more in obese dogs and c.1121C>G (p3Pro374Arg) was found more in lean dogs. We found 5 synonymous and 4 non-synonymous variants in the canine GPR120 gene, in which c.595C>A (p.Pro199Thr) was found more in obese dogs. The variant c.595C>A (p.Pro199Thr) was found only in beagles. These findings will be applied to clinical nutrition in dogs.
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| Free Research Field |
獣医学
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