2014 Fiscal Year Final Research Report
A sustainable and enantioselective process based on chiral spiro-type catalysis
| Project/Area Number |
24590009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 不斉 / スピロ / 環境調和 |
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| Outline of Final Research Achievements |
Chiral ligands and organocatalysts with a spiro skeleton have received considerable attention in asymmetric catalysis because of their unique structural properties and high asymmetric induction efficiency. However, enantioselective synthesis of optically pure spirobicyclic compounds remains a formidable task because the chiral catalysts must control not only the enantiodiscrimination but also the formation of the quaternary carbon center. We have developed the facile synthesis of chiral spirobicycles through the Pd-catalyzed intramolecular α-arylation of α-substituted cyclic ketones. The absolute configuration of spirocyclic ketone was assigned as S by X-ray analysis.
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| Free Research Field |
有機合成化学
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