Development of sheet formulation containing anticancer drugs and gene medicine for application to liver surface

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: NISHIDA Koyo 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (20237704)
• Research Collaborator: MINE Toyoharu ; MIYAMOTO Hirotaka ; HIRATA Haruna ; YOSHIKAWA Naoki
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: がん / 製剤 / コントロールドリリース

Outline of Final Research Achievements

We tried to manufacture the sheet formulation containing anticancer drug 5-FU for application to liver surface. In addition, we examined the influence of metabolic inhibitors on the hepatic disposition of 5-FU, aiming to optimize the sheet formulation. We could manufacture the sheet formulation containing anticancer drug 5-FU for application to liver surface by employing biodegradable macromolecules poly (lactic-co-glycolic acid) and hydroxypropyl cellulose. From the sheet formulation, the containing 5-FU was gradually released for a long period time. Moreover, we found that gimeracil a metabolic inhibitor was useful to improve the bioavailability of 5-FU in the liver, and obtained the optimal combination ratio.

Free Research Field

薬剤学