2014 Fiscal Year Final Research Report
Basic research of macromolecular DDS carriers aiming for resistance mechanism of anticancer drug
| Project/Area Number |
24590070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UN Keita (80624535)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ナノ医薬品 / 高分子キャリア / 抗癌剤 / トランスポーター |
|---|
| Outline of Final Research Achievements |
We evaluated the intracellular trafficking including efflux of liposome components. We further evaluated the ability of liposome components to inhibit the efflux of doxorubicin from P-gp whose over-expression in tumor cells can cause the resistance to anticancer drugs. It was indicated that the PEGylated lipid was involved in the in-vitro cytotoxicity of the doxorubicin-loaded liposomes. It was also found that PEGylation or charge of the liposome components largely affected the in-vitro cytotoxicity of the doxorubicin-loaded liposomes.
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| Free Research Field |
医薬品評価科学
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