Regulation of adaptive responses to hypoxia and glucose deprivation by NAD-dependent deacetylase SIRT7

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: NAKAGAWA KOJI 北海道大学, 薬学研究科(研究院), 講師 (80360949)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Masanobu 北海道医療大学, 看護福祉学部, 教授 (80241321)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 低酸素応答 / 低グルコース応答 / SIRT7 / 脱アセチル化酵素 / HIF-1 / MDM2

Outline of Final Research Achievements

In this project, we investigated the physical and functional interactions between SIRT7 (sirtuin-7) deacetylase and HIF-1(hypoxia inducible factor-1). It was found that SIRT7 physically associates with HIF-1α and enhances the expression of HIF-1-target genes. Moreover, we also found that SIRT7 directly associates with E3-ubiquitin ligase MDM2 (murine double minute 2), which is known to enhance the transcriptional activity of HIF-1, and increases the protein stability of MDM2.

Free Research Field

分子生物学・生物系薬学