Role of thermo-sensitive TRP channels in stress-induced visceral hyperesthesia: analyses of samples from disease model animals and patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Josai International University
• Principal Investigator: HORIE SYUNJI 城西国際大学, 薬学部, 教授 (50209285)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: TRPチャネル / カプサイシン / 痛覚過敏 / 知覚過敏 / 微小炎症 / ストレス / 過敏性腸症候群 / 機能性ディスペプシア

Outline of Final Research Achievements

Psychological stress induces impairment of gastrointestinal tracts, leading to functional gastrointestinal diseases (irritable bowel syndrome, functional dyspepsia) accompanied by abdominal pain. The present study was designed with those disease model animals in order to elucidate the causes of functional gastrointestinal diseases. As an important result, the stress induces the increased number of thermosensitive TRP channel-expressing nerve fibers, resulting in the hypersensitivity of visceral pain. Therefore, the inhibition of the abnormality of TRP channels-expressing nerves in gut will make a contribution to the treatment of functional gastrointestinal diseases.

Free Research Field

神経消化器病の原因究明と医薬品の薬効評価