2014 Fiscal Year Final Research Report
Attenuation of tumor growth in TRPM2 knockout mice and its mechanism
| Project/Area Number |
24590124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Yokohama College of Pharmacy (2014)
Showa University (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Masakazu 昭和大学, 薬学部, 准教授 (30307061)
NEGORO Takaharu 昭和大学, 薬学部, 講師 (70218270)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ＴＲＰＭ２ / 固形がん / カルシウムイオン / サイトカイン / 血管新生 / マクロファージ |
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| Outline of Final Research Achievements |
This study examined whether TRPM2 channels contribute to tumor growth. The tumor growth by injection s.c. with lung cancer cells was suppressed in TRPM2 knockout (KO) mice. Angiogenesis, number of macrophages and angiogenesis-stimulating cytokines, all of which are stimulating factors for tumor growth, were increased in the tumor of TRPM2 KO mice. Moreover, TRPM2 expression was observed in macrophages, and the channels were activated by H2O2. These findings suggest that TRPM2 channels in macrophages contribute to tumor growth, and may be a candidate as target molecule for new anti-cancer drug.
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| Free Research Field |
病態学
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