2014 Fiscal Year Final Research Report
Design, synthesis and functional studies of small molecules that modulate protein-protein interactions
| Project/Area Number |
24590136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 天然物合成 / タンパク質間相互作用 / 創薬化学研究 / 8員環形成 / コチレニン |
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| Outline of Final Research Achievements |
Synthetic study of cotylenin A, a natural product which stabilize protein-protein interactions was carried out. A-ring part was synthesized with intramolecular aldol reaction from optically active perillyl alcohol stereoselectively. Furthermore, Construction of 8-membered ring of B-ring part was accomplished by ring closing metathesis reaction via the coupling reaction of A-ring and C-ring and the subsequent functionalizations. Now we are working on stereoselective incorporation of two hydroxyl groups. On the other hand, we are almost finished synthesis of two parts of sugar-moiety. We will assemble these two parts by double acetalization reaction. And we are planning to complete total synthesis of cotylenin A, synthesize derivatives and analyze functions of synthesized compounds.
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| Free Research Field |
創薬化学研究
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