Studies focused on discovery of micro RNA function for biomarkers in chemotherapy against lung cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: SHIBAYAMA Yoshihiko 北海道大学, 薬学研究科(研究院), 准教授 (90593822)
• Co-Investigator(Renkei-kenkyūsha): ISEKI Ken 北海道大学, 大学院薬学研究院, 教授 (40203062) ; AKITA Hirotoshi 北海道大学, 大学院医学研究科, 教授 (70222528)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌 / マイクロRNA / バイオマーカー

Outline of Final Research Achievements

MicroRNA (miRNA) is a non-cording RNA that regulates protein synthesis by mRNA translations, which is critically involved in various physiological processes. We evaluated the relationship among survival in cancer patients, the expression level in patient’s plasma and function of miRNAs. Lower miRNA101-5p expression levels were correlated with a lower probability of survival in lung cancer patient. Lower miRNA124-5p expression levels were also correlated with a lower probability of survival in colon cancer patients. The transfection of mimic miRNA124-5p into cancer cells inhibited cell growth. Our results indicate that expression levels of miRNA101-5p and miRNA124-5p related with survival; expression levels of miRNA101-5p and 124-5p may be used as biomarkers to determine the prognosis of cancer patients.

Free Research Field

医療薬学